One-pot sequential synthesis of fused and non-fused poly-substituted dihydropyridine derivatives under catalyst-free conditions, By Dariush Saberi

Research

Title	One-pot sequential synthesis of fused and non-fused poly-substituted dihydropyridine derivatives under catalyst-free conditions
Type	Article
Keywords	Dihydropyridine One-pot α,β-Unsaturated aromatic ketones Condensation reaction
Journal	TETRAHEDRON
DOI	10.1016/j.tet.2024.134279
Researchers	fatemeh asilpour (First researcher) , Dariush Saberi (Second researcher) , Alireza Hasaninejad (Third researcher)

Abstract

A one-pot, sequential, three-component procedure is reported for the synthesis of poly-substituted dihydropyridines via the condensation reaction of diamines or aminophenoles, 1,1-bismethylmethio-2-nitroethylene and α,β-unsaturated aromatic ketones in acetonitrile under reflux conditions. A range of fused and non-fused polysubstituted dihydropyridines were prepared in good to high yields with short reaction times.