The novelest advantage of honeycomb composite panels being compared to usual solid plates is their high strength to weight ratio. Wide application of these materials in different industries such as marine and aerospace needs expanded study of their behavior in interaction with different fluids. Therefore, in this thesis we have tried to investigate the effect of adding honeycomb core to a usual solid plane and studied the structure’s responses facing waves with different velocities (5, 10, 15, 20 and 25 m s-1) by taking advantage of ANSYS software capabilities. As the first stage, one solid beam and two honeycomb beams with different core thicknesses were modeled as cantilever structures. Strength to weight ratio and maximum bearing load of each was studied. It was seen that adding the honeycomb core lead to increase the strength to weight ratio. The more the thickness of the core, the ratio was more, too. Continuing modellings with three other beams with different core configurations (triangular, rectangular and honeycomb), modal analysis has been executed and the shape modes and natural frequencies has been compared. The beam with the rectangular core had the highest natural frequency, meaning that it has higher bending stiffness and less weight. At last, by providing a coupling between fluid and structural modules of the software, one-way Fluid-Solid interaction analysis is simulated for two panels (solid and honeycomb) with the same dimensions. Pressure and velocity charts and contours of the fluid around the solid models and the deflection and equivalent Von-Mises stress contours has been extracted. Honeycomb panel shows better results when it’s exposed to a fluid and the authenticity of simulation was well stablished.