فاطمه احمدی

Introduction: Exercise and supplementation have different effects on indicators of myocardial cell damage. The purpose of this research is to investigate the effect of 8 weeks of resistance training with spirulina consumption on changes in cardiac troponin T, brain natriuretic peptide and creatine kinase in order to investigate cardiac muscle damage. Methods: Thirty-two male Sprague—Dawley rats 150±20 g in weight, and 9 weeks of age were divided into four groups, which included control (CO), resistance training (RT), spirulina (SP), and resistance training with spirulina (RTS). Spirulina was orally administered to rats in SP and RTS groups at a dose of 200 mg/kg per day. The resistance training protocol consisted of eight weeks of climbing a 1-meter high ladder. The expression levels of cardiac troponin T (cTnT), brain natriuretic peptide (BNP), creatine kinase-myocardial membrane (CK-MB) variables were measured using real-time PCR method. Results: The findings of this research showed that 8 weeks of resistance training caused a significant increase in cTnT(P=0.044), BNP(p=0.001) and CK-MB(p=0.015) levels. Also, in the spirulina group and the spirulina + exercise group, the amount of cTnT (respectively p=0.005, p=0.001) and BNP (respectively p=0.002, p=0.0001) decreased significantly, which was more in the spirulina + exercise group. In addition, there was a decrease in CK-MB in the spirulina group (p = 0.001) and the spirulina + exercise group (p = 0.115), which was significant in the spirulina group. Conclusion: Spirulina supplementation can be an effective factor in preventing myocardial damage during resistance exercise by reducing the indicators of myocardial cell damage caused by resistance exercise.