Recently, Bafekry et al. [Applied Surface Science 582 (2022) 152356] presented their density functional theory (DFT) results on the electronic, optical and elastic properties of the Pd4P4Se2X2 (X = O, S, Te) Janus monolayers. The aforementioned theoretical work however includes errors in introducing the structures, evaluation of electronic band structures and predicted elastic constants, as will be discussed in this comment.