Fazel Shojaei

Given the importance of pyrrolo[3,2-d]pyrimidine derivatives in medicinal chemistry and industry, simple and efficient methods for the synthesis of these compounds are constantly being developed. In the first part of this study, the reaction between acenaphthoquinone and various 6-aryl amino uracils was investigated with the aim of synthesizing new compounds containing the pyrrolo[3,2-d]pyrimidine core. This reaction was carried out in polyethylene glycol as the solvent and in the presence of p-toluenesulfonic acid as a catalyst at 90 °C. Azocines are eight-membered nitrogen-containing rings found in the structures of many natural, pharmaceutical, and biologically active compounds. Owing to their biological significance and wide applications in medicinal chemistry, various methods have been developed for the synthesis of azocine rings. Accordingly, in the second part, the reaction between ninhydrin and 6-amino uracils was examined. This reaction was performed in ethanol under reflux conditions in the presence of p-toluenesulfonic acid as a catalyst, leading to the formation of azocine derivatives.