Water, a necessary component of cell protoplasm, plays an essential role in supporting life on
Earth; nevertheless, extreme changes in climatic conditions limit water availability, causing numerous
issues, such as the current water-scarce regimes in many regions of the biome. This review aims to
collect data from various published studies in the literature to understand and critically analyze plants’
morphological, growth, yield, and physio-biochemical responses to drought stress and their potential
to modulate and nullify the damaging effects of drought stress via activating natural physiological and
biochemical mechanisms. In addition, the review described current breakthroughs in understanding
how plant hormones influence drought stress responses and phytohormonal interaction through
signaling under water stress regimes. The information for this review was systematically gathered
from different global search engines and the scientific literature databases Science Direct, including
Google Scholar, Web of Science, related studies, published books, and articles. Drought stress
is a significant obstacle to meeting food demand for the world’s constantly growing population.
Plants cope with stress regimes through changes to cellular osmotic potential, water potential, and
activation of natural defense systems in the form of antioxidant enzymes and accumulation of
osmolytes including proteins, proline, glycine betaine, phenolic compounds, and soluble sugars.
Phytohormones modulate developmental processes and signaling networks, which aid in acclimating
plants to biotic and abiotic challenges and, consequently, their survival. Significant progress has
been made for jasmonates, salicylic acid, and ethylene in identifying important components and
understanding their roles in plant responses to abiotic stress. Other plant hormones, such as abscisic
acid, auxin, gibberellic acid, brassinosteroids, and peptide hormones, have been linked to plant
defense signaling pathways in
