Green-synthesized copper oxide nanoparticles induce apoptosis and up-regulate HOTAIR and HOTTIP in pancreatic cancer cells, By Hossein Nikmanesh

Research

Title	Green-synthesized copper oxide nanoparticles induce apoptosis and up-regulate HOTAIR and HOTTIP in pancreatic cancer cells
Type	Article
Keywords	algae; arsenic trioxide; chemoresistance; copper; long non-coding RNA
Journal	Nanomedicine
DOI	https://doi.org/10.1080/17435889.2024.2367958
Researchers	Amirhossein Ahmadi (Second researcher) , Ahmad Shadi (Third researcher) , Seyed Javad Hosseini (Fourth researcher) , Hossein Nikmanesh (Fifth researcher)

Abstract

Aim: Cu2O nanoparticles were synthesized using an extract from S. latifolium algae (SLCu2O NPs). Their effect on PANC-1 cells and the expression of two drug resistance-related lncRNAs were evaluated in comparison with Arsenic trioxide. Materials & methods: SLCu2O NPs were characterized using XRD, SEM, and TEM microscopies. The effects of SLCu2O NPs on cell cytotoxicity, cell cycle, and apoptosis, and expression of two drug resistance-related lncRNAs were examined using MTT assay, flow cytometry, and real-time PCR,respectively. Results: SLCu2ONPs demonstrated anti-cancer properties against PANC-1 cells comparable to Arsenic trioxide, and the expression of lncRNAs increased upon treatment with them. Conclusion: SLCu2O NPs demonstrate anti-cancer properties against PANC-1 cells; however, using gene silencing strategies along with SLCu2O NPs is suggested.