Heterocycles are an important class of organic compounds due to their unique biological properties, pharmaceutical, cosmetics chemistry, and industry. So, the synthesis of new and important types of heterocyclic compounds in green and eco-friendly conditions continues to attract wide attention among synthetic chemists. In the first part of this thesis, the multicore metal alloy (Fe50-Co30-Ni20) is prepared and characterized by FT-IR spectroscopy, field emission scanning electron microscopy (FE-SEM), X-ray (XRD), and elemental analysis. These multicore metal as well as aluminum sulfate are used as catalysts for the synthesis of 2,3-dihydroquinazolines which are shown a wide range of biological activities and medicinal properties. The synthesis is performed by the reaction between isatoic anhydride, aniline derivatives, and aromatic aldehydes in the presence of a catalyst (Fe50-Co30-Ni20). It worths to mention, a novel class of pyrazole quinazolines is synthesized by replacing of an aromatic aldehyde with 5-Chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde using mentioned catalysts in refluxing ethanol.
In the next section, several biological properties of dihydroquinazoline and especially pyrazole quinazoline have been studied. Antibacterial, antioxidant properties, hematological activities, blood factor assays, alpha-glycosidase inhibitory activity, docking studies, and related statistical analyzes were evaluated by the Korris Calvalis test. The results showed antioxidant and effective treatment of Alzheimer's and diabetes simultaneously.
In the third part of this thesis, multicore complexes [choline]+[Cu3Cl4]‾ catalyst is prepared and characterized by SEM, Mass spectra, and UV visible. 2,3-Dihydroquinazolines are synthesized in the presence of [choline]+[Cu3Cl4]‾ as a catalyst in good to excellent yields. In order to understand the mechanism and intermediates, the reaction progress was monitored by high performance liquid chromatography (HLPC) and two intermediat