The desiccant wheel, or in other words, wheel dehumidifier is a equipment that can be used as a part of the air conditioning system to increase the efficiency of the system or as an independent system to supply dry air. Modeling is an effective method for analyzing the performance of the rotary desiccant wheel, which can be used to interpret the empirical results and help the system design. The desiccant wheel modeling was formed to close the actual conditions of the wheel, taking into account the resistance to moisture transfer on both sides of the gas (air flow) and solid (adsorbent layer). The dimension of the equations was carried out by the dimensional numbers and the discussion of the equations without the differential quadrature method. Finally, the algebraic equations obtained from the discussion by Newton Raphson Method continued to repetitively until the answer is accurately. The simulation of the desiccant wheel was performed in the MATLAB software environment, the simulation results showed that the differential quadrature methods have high accuracy and speed in solving the desiccant wheel problems and can be a good alternative to the common numerical methods in solving these problems such as finite difference and finite volume. Wheel simulation was performed for both silicagel and zeolite adsorbents, better performance of silicagel wheel according to the properties and isoterm equation. In this study, the simulation of the desiccant wheel was performed using more than one adsorbent along the channel bed, which showed that the silicagel desiccant wheel could increase 3% the wheel's performance in the removal of moisture from air if zeolite was used at the end of the channel bed. As a result, wheels can be designed using multi -adsorbent that performs better in removing air humidity than the usual wheel mode, which only uses one adsorbent.