Introduction and purpose: The emergence of the dangerous and deadly disease Covid-19 at the end of 2019 in Hubei city, Wuhan province of China and its rapid spread caused a wide and global impact on the health, mental security, economy, culture and politics of different countries, which attracted the attention of the medical community and related sciences has been paid to identify and treat this disease. Various studies conducted on this disease indicate the identification of a new coronavirus as its cause.
Since coronaviruses infect humans with different degrees of severity and lethality. Four of these viruses (NL63, E229, OC43, and HKU1) cause mild respiratory problems in humans, and three others (MERS CoV, SARS-CoV, including the newly emerged SARS-CoV-2) can cause severe respiratory syndromes. According to researches, various chromosomal genes and loci can play a role in the severity of the covid-19 disease, and several studies have been conducted on their single nucleotide polymorphism, and the purpose of this study is to investigate the single nucleotide polymorphism of rs17713054 in the 3p21 region. 31 on the LZFTL1 gene and its relationship with disease severity in patients with covid-19 in Bushehr province, Iran.
Materials and methods: In this study, peripheral blood samples from 150 patients with covid-19 (90 mild covid-19 patients and 60 severe covid-19 patients, men and women of Bushehr province, from Persian Gulf and Tamin hospitals social and saliva samples from friends and people in student dormitories were collected for two months and DNA extraction from white blood cells and saliva was done using phenol chloroform method. Determination of A and G alleles in both groups of people with The PCR operation and sequencing was determined by Sinoha Shiraz Company. Data analysis and investigation of the association of A and G alleles with people with severe and mild type of covid-19 was done using SPSS software and the p-value was greater than 0.05 and was n
