A simple, highly efficient and green procedure for the condensation of aryl and alkyl 1,2diamines with ?-diketones in the presence of catalytic amounts of metalloporphyrins at room temperature is described. Using this method, quinoxaline derivatives as biologically interesting compounds are produced in high to excellent yields and short reaction times. In this report, the effects of central metal in porphyrin core and substituents on tetraphenylporphyrin skeleton have been studied.