Abstract: The aim of the current research is to design and synthesize schiff base nanocatalysts on nanomagnetic substrate and investigate its catalytic effect in the oxidation of alkenes and alcohols. This research is presented in two separate parts. In the first part, iron oxide magnetic nanoparticles functionalized with silica (Fe3O4@SiO2) were functionalized by 3-aminopropyltrimethoxysilane and the composition Fe3O4@SiO2@APTMS was obtained. Fe3O4@SiO2@APTMS@PYC composite was prepared from the condensation of the carbonyl group of 2-pyrrolecarbaldehyde with amine groups on the Fe3O4@SiO2@APTMS surface. Then, through the salts of copper (II) acetate, cobalt (II) acetate, manganese (II) acetate, nickel (II) acetate and vanadyl acetylacetonate with schiffbase , nano catalysts Fe3O4@SiO2@APTMS@PYC@M (M= Cu, Co, Ni, V) were synthesized. All synthesized compounds were identified using FT-IR, mass, TEM, SEM, TGA, ICP-OES, XRD and VSM methods. The catalytic activity of Fe3O4@SiO2@APTMS@PYC@Cu was investigated for the oxidation of alkenes and alcohols in the presence of tert-butyl hydroperoxide. From the oxidation of norbornene, the product 2-norbornenanone was obtained with 99% conversion and 100% selectivity. Next, the antibacterial activity of Fe3O4@SiO2@APTMS@PYC@Cu was also investigated and compared to the standard antibiotic, it completely stopped the growth of E. Coli and S. aureus bacteria. In the second part, the compound Fe3O4@SiO2@APTMS@Tuc was prepared from the condensation of the carbonyl group of the compound 2-thiophenecarbaldehyde with amine groups on the surface of Fe3O4@SiO2@APTMS, then through copper (II) acetate, cobalt (II) acetate and trioxide molybdenum salts, with schiffbase, nano catalysts Fe3O4@SiO2@[APTMS@Tuc@M](OAc)2(M=Cu, Co, Mo) were synthesized. The catalytic activity of Fe3O4@SiO2@[APTMS@Tuc@Cu](OAc)2 for the oxidation of alkenes and alcohols in the presence of tert-butyl hydroperoxide was investigated. From the oxidation of benzyl alcohol,