Copper catalyzed reaction of alcohols, alkyl halides and Na2S2O3: An odorless and ligand-free rout to unsymmetrical thioether synthesis, By Mohammad Abbasi

Research

Title	Copper catalyzed reaction of alcohols, alkyl halides and Na2S2O3: An odorless and ligand-free rout to unsymmetrical thioether synthesis
Type	Article
Keywords	thioether, Na2S2O3, thiol, Bunte salt
Journal	NEW JOURNAL OF CHEMISTRY
DOI	https://doi.org/10.1039/D2NJ03164G
Researchers	Mohammad Abbasi (Second researcher)

Abstract

A CuI-catalyzed condensation reaction between alcohols, alkyl halides, and Na2S2O3 leading to structurally diverse thioethers is reported. A variety of alkyl halides and electron-rich benzyl alcohols were employed successfully in the presence of 5 mol% CuI in PEG-200 at 110 C. The method does not require any ligands or additives. The unsymmetrical thioethers were achieved in good to excellent yields within appropriate reaction times.