I2‑catalyzed one‑pot oxidative condensation of thiourea, methyl ketones, and aryl thiols into 5‑sulfenylated 2‑amino‑1,3‑thiazoles by DMSO, By Mohammad Abbasi

Research

Title	I2‑catalyzed one‑pot oxidative condensation of thiourea, methyl ketones, and aryl thiols into 5‑sulfenylated 2‑amino‑1,3‑thiazoles by DMSO
Type	Article
Keywords	Thiazoles · Methyl ketones · Thiols · Thiourea
Journal	MOLECULAR DIVERSITY
DOI	https://doi.org/10.1007/s11030-022-10585-4
Researchers	Mohammad Abbasi (First researcher) , Najmeh Nowrouzi (Second researcher) , sara sajedinia (Third researcher)

Abstract

A one-pot, efficient oxidative-condensation process for constructing both 4-alkyl and 4-aryl-5-(arylthio) thiazol-2-amines using DMSO/I2 is introduced. In this procedure, methyl ketones, thiourea, DMSO, and thiols are reacted together in the presence of molecular I2 at 80 °C simply to produce 4-alkyl or aryl-5-(arylthio)thiazol-2-amines due to formation of a C–S bond between thiourea and methyl carbon linked to carbonyl group and the another C–S bond formation between thiol and thiazol ring. Under reaction conditions, both aryl and alkyl methyl ketones including acetophenone and substituted acetophenones also, 2-alkanones such as acetone, 2-butanone, 2-pentanone, and 2-heptanone yield those products successfully.