Mohammad Abbasi

The Synthesis of one-pot 2-amino-5-aryl thio-1, 3 Thiazoles involves a streamlined and efficient method to produce complex thiazole derivatives. Thiazoles are a significant class of heterocyclic compounds with wide-ranging applications in pharmaceuticals, agrochemicals, and materials science. These compounds exhibit various biological activities, including antimicrobial, anti-inflammatory, and anticancer properties. Traditional synthetic routes to these compounds often involve multi-step processes with limited yields. Therefore, the development of efficient and straightforward synthetic methodologies is of great importance The one-pot approach simplifies the synthetic procedure, reduces reaction time, and minimizes the need for intermediate purifications, offering a robust and practical solution for the synthesis of bioactive thiazole compounds. This study involves the one-pot synthesis of 1,3-thiazole. The reactants, thiourea, a methyl ketone, and thiophenols, are reacted in the presence of N-iodosuccinimide in DMSO at 80°C. After the reaction is complete the product is extracted and recrystallized for further purification.