One-pot efficient synthesis of b-aryl-b-sulfanyl ketones via a four-component reaction of alkyl halides, thiourea benzaldehydes and acetophenones, By Mohammad Abbasi

Research

Title	One-pot efficient synthesis of b-aryl-b-sulfanyl ketones via a four-component reaction of alkyl halides, thiourea benzaldehydes and acetophenones
Type	Article
Keywords	—
Journal	TETRAHEDRON LETTERS
DOI	—
Researchers	Mohammad Abbasi (First researcher) , Najmeh Nowrouzi (Second researcher) ,

Abstract

A one-pot efficient synthesis of b-aryl-b-sulfanyl ketones is introduced via a tandem aldol condensationthia- Michael addition process using NaOH in the poly ethylene glycol (PEG-200). Addition of different thiols in situ generated from the reaction of alkyl halides with thiourea to chalcones, formed in situ from the condensation of acetophenone derivatives with benzaldehydes, led to a high yielding synthesis of the products.