Mahmood Barani

This review examined the advancements in microfluidic-based synthesis of niosomes and their applications in cancer and infection therapies. Niosomes, vesicles known for their biocompatibility, stability, and ability to encapsulate a wide range of therapeutic agents, emerged as promising candidates for targeted drug delivery. The integration of microfluidic technology into niosome production offered several advantages over conventional methods, including precise control over particle size, faster and more reproducible fabrication, and improved drug delivery efficiency. This review discussed the principles of microfluidic systems, optimization strategies for niosome synthesis, and the characterization techniques used to assess their physicochemical and biological properties. Additionally, it explored the therapeutic applications of microfluidic-synthesized niosomes, high­ lighting their potential in treating various cancers, such as breast, lung, brain, liver, and colorectal cancers, as well as their effectiveness in combating infections, including bacterial, fungal, viral, and parasitic diseases. By summarizing these developments, the review emphasized the transformative impact of microfluidic technology in advancing niosome-based therapies and improving clinical outcomes