Before the beginning of the Safavid era, commerce in the Persian Gulf region had achieved unprecedented growth and development by relying on extensive shipping and free trade, and one of the reasons for this can be the insecurity and political turmoil in the region and the lack of stability in land routes and Blue is known in East and West trade. In that era, Persian Gulf trade and seafaring, although it was managed by Iranian and native merchants and sailors, but it did not have an exclusive flavor in any way, and merchants from all races and religious and ethnic groups, as well as from all countries, participated in it. They were partners and there were no exclusive and special rights for a specific group. It should also be kept in mind that the Persian Gulf was not the only center for the collection and export of local goods in the region, or the place for importing goods and items needed by the region, but as the main and important point and center in the trade relations between the East and the West, it played a special role. and Hormoz Island was considered the main base. Considering the importance of the Persian Gulf in terms of its political geography and socio-economic constructions, the topic of this research is novel and pristine from an academic point of view, because no work with this title has been presented in the official higher educational and research centers of Iran. The purpose of this research is to investigate the economic-political structure of the Persian Gulf region and its effect on the commercial activities of foreign companies in the Safavid era. Therefore, this research aims to fulfill the goal of analyzing and critically examining past researches according to sociological and economic perspectives and political theories. The results of this research, considering the important situation of the Persian Gulf, will lay the foundations for future research. The research method in this research is descriptive-analytical and based on the collec