Afterglow properties of CaF2:Tm nanoparticles and its potential application in photodynamic therapy, By Mohsen Mehrabi

Research

Title	Afterglow properties of CaF2:Tm nanoparticles and its potential application in photodynamic therapy
Type	Article
Keywords	CaF2:Tm Nanoparticles Afterglow Photodynamic therapy
Journal	JOURNAL OF LUMINESCENCE
DOI	10.1016/j.jlumin.2015.11.043
Researchers	Mostafa Zahedifar (First researcher) , Ehsan Sadeghi (Second researcher) , Mohammad Mahdi Shanei (Third researcher) , Ameneh Sazgarnia (Fourth researcher) , Mohsen Mehrabi (Fifth researcher)

Abstract

CaF2:Tm nanoparticles (NPs) were synthesized by the hydrothermal method. Intense afterglow emission with long life time was found for the produced NPs, so its applicability in photodynamic therapy was investigated. Since the wavelength of the afterglow emission of the NPs fairly matches with the absorption band of the PpIX sensitizer, especially in the red region, the Cystein mediator was used to bond NPs with the PpIX sensitizer. The CaF2:Tm NPs conjugated with PpIX was exposed to X-ray and by using the Antracene as detector, the production of the singlet oxygen was verified. Therefore, the produced NPs are recommended as a source of energy that improves photodynamic therapy beyond its current limitations.