Mohsen Mehrabi

Photothermal and chemodynamic therapy are two advanced treatment methods that have attracted a lot of attention recently. In photothermal therapy, light (such as laser or infrared light) and light-absorbing materials are used to locally heat body tissues, which leads to the selective destruction of cancer cells through hyperthermia. Chemodynamic therapy uses Fenton-like reactions and the generation of hydroxyl radicals to effectively target and kill cancer cells. These two methods offer the potential for targeted, minimally invasive cancer treatment with the ability to protect healthy tissues from damage. In this research, first, mesoporous silica nanomaterials were synthesized using soft template by sol-gel method. In the next step, copper sulfide and copper sulfide nanoparticles doped with iron, molybdenum, manganese, silver and nickel stabilized with bovine serum albumin were synthesized under the same conditions and with similar molar amounts, and then their visible and ultraviolet spectra were taken. In this group, copper sulfide doped with molybdenum and iron showed the highest absorption in the wavelength region of 808 and especially 1100 nm near to the first IR window (750-1000 nm). Therefore, molybdenum and iron metals can be suitable candidates in the synthesis of copper sulfide nanoparticles as efficient photothermal therapy absorbers in the near infrared region. In the next step, some of the solution of each sample was exposed to 808 nm laser radiation with a power of 1000 mW, the effects of photothermal of all samples were observed, recorded and compared with each other with a temperature sensor. Copper sulfide doped with iron and molybdenum metals showed the most photothermal effects according to the absorption spectrum. Then the chemodynamic therapy effects of these nanoparticles were investigated and compared. that copper sulfide doped with molybdenum metal showed the best performance. Finally, copper sulfide doped with iron and molybdenum metals wer