In the present study, the effects of dietary supplementation of low molecular weight sodium alginate on growth factors, body composition, antioxidant enzymes, digestive enzymes and immune response in yellowfin seabram juvenile (Acanthopagrus Latus) were investigated. For this purpose, fish (with initial body weight of 0.5±0.002 g) were fed into 3 treatments with 3 replicates for 8 weeks. Dietary treatments were used in this study including: basal diet without sodium alginate (control treatment), basal diet containing 5 g sodium alginate per kg diet (0.5 % treatment) and basal diet containing 10 g sodium alginate per kg diet (1% treatment). At the end of the experiment sampling and biometry were done. The results of the present study showed that the final weight, weight gain, specific growth rate, condition factor and daily feed intake obtained in the control treatment was significantly the highest value and 1% treatment had the lowest value (P < 0/05). However, significant difference was observed between the control and 0.5 % treatments (P > 0.05). Moreover, the feed conversion ratio and protein efficiency ratio of the control treatment significantly showed the lowest and highest value (1.08 ±0.06) and the 0.5% treatment had the highest and lowest value (P <0.05). But, significant difference was observed between the control and 1 % treatments (P> 0.05). The obtained results indicated that dietary sodium alginate did not affect body composition including protein, fat and moisture (P > 0.05). In the present study, the activity of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) in the groups fed on 0.5 and 1 % sodium alginate showed significantly increase compared to the control group (P < 0.05). But, the activity of lipid peroxidation (MDA) in the groups fed on 0.5 and 1 % sodium alginate showed significantly decrease compared to the control group (P < 0.05). The results also showed that the activities of digestive enzymes such as lipase, protease an