The metal pollution in Sediments and Avicenna marina tissues in the Hara Biosphere Reserve was monitored for Lead (Pb), Cadmium (Cd), and Nickel (Ni) with atomic absorption spectrometer. The results showed that the mean concentration of Pb, Cd, and Ni in the water and sediments were much higher than the recommended threshold limits in the most stations, also the highest means of Pb, Cd, and Ni were observed in Avicenna roots and it were 25.26 ± 4.86, 2.17 ± 0.74, and 26.72 ± 6.17 (?g g?1) respectively. Calculating BCF (bioconcentration factor) index illustrates that A. marina accumulates Pb, Cd, and Ni 1.62, 1.52 and 0.73 times greater than sediment levels respectively, So it can show that A. marina may be employed as a biological indicator exposure of Cd, Pb, and Ni with temporal monitoring, also the factories were main sources of metals contamination in the Hara Biosphere Reserve.