Organic dyes are among the water pollutants, which enter the aquatic environment through petrochemical, textile, rubber, paper, plastic and cosmetic wastes. Waters polluted with colored effluents have different effects on the environment. Hence, in the current study, by synthesizing the Ag2O@ZnO catalytic system stabilized on the g-C3N4 substrate modified with the magnetic iron nanoparticles has been tried a new and efficient approach for reducing the industrial wastewater pollution load. Methylene blue is a carcinogenic pollutant, which have dangerous effects on humans and marine ecosystems. Recently, the degradation of methylene blue with photocatalyst has been proposed as an advanced approach in removing this harmful dye from aquatic environments. Towards this purpose, the novel g-C3N4@Fe3O4@Ag2O@ZnO photocatalysis was synthesized. Then, its application for removing of methylene blue from wastewater was investigated by considering and optimizing a broad range of effective parameters in the experimental conditions and under the UV radiation. To attain the best removal condition, the response surface method was used. The characterization of the novel synthesized photocatalyst was evaluated by FTIR, XRD, BET, FE-SEM, VSM, and TGA analyses. The ranges of effective parameters on the removal efficiency in the present investigation was as follows: (50-100 mg/L), photocatalyst dose (0.1-0.5 g), reaction time (15-90 min), and pH (3-11). The peaks observed in the FTIR and XRD analyses confirmed the accuracy of g-C3N4@Fe3O4@Ag2O@ZnO photocatalyst synthesis. TGA analysis showed high thermal stability of the synthesized photocatalyst. However, the FE-SEM analysis proved the presence of planar and spherical structures, which were respectively affected by the presence of g-C3N4 and g-C3N4@Fe3O4, and irregular planar structures, indicating the presence of zinc and silver in the final nanostructure. Investigating the physical properties of the final photocatalyst showed that its