In this study, the possibility of preparing fresh water through the environmentally friendly process of hybrid electrodialysis (ED)-revers electrodialysis (RED) has been investigated. Therefore, process performance has been evaluated and modeled with real and synthetic concentrated brine with high salinity up to 200000 ppm from Persian Gulf sea water and synthetic and real brackish water with the salinity of up to 7240 ppm from rivers in Bushehr province, Iran. Results demonstrated that the RED system was capable of generating the energy needed to desalinate brackish water with the salinity of less than 1000 ppm, but an extra amount of electrical energy is required for the desalination of samples with a higher salinity of up to 4000 ppm. Results showed the best performance of process for brackish waters with initials concentrations of 1000, 2000 and 4000 ppm was 42, 53 and 52%, respectively. It was also revealed that due to the presence of a variety of minerals and high salinity in river waters, the rate of electricity production and desalination was less than that of the synthetic water samples on a pilot scale; e.g., for the Mond River with an initial salinity of 2690 ppm, the salinity reduction was around 27.17%.