A novel, chemoselective one-pot procedure for the preparation of 3H-spiro[isobenzofuran-1,20-pyrrole]-3,30(10H)-dione derivatives via oxidative cleavage of 3a,8b-dihydroxyindeno[1,2-b]pyrroles, By Mohammad Reza Mohammadizadeh

Research

Title	A novel, chemoselective one-pot procedure for the preparation of 3H-spiro[isobenzofuran-1,20-pyrrole]-3,30(10H)-dione derivatives via oxidative cleavage of 3a,8b-dihydroxyindeno[1,2-b]pyrroles
Type	Article
Keywords	—
Journal	TETRAHEDRON LETTERS
DOI	—
Researchers	Mohammad Reza Mohammadizadeh (Second researcher) ,

Abstract

A one-pot, efficient and chemoselective procedure for the synthesis of new 3H-spiro[isobenzofuran-1,20- pyrrole]-3,30(10H)-dione derivatives has been developed which involves room temperature oxidative cleavage of 3a,8b-dihydroxyindeno[1,2-b]pyrroles themselves synthesized from the reaction of ninhydrin and enaminones in 30% ethanol. A reasonable mechanism is proposed for the oxidation reaction based on the results of this study and our previous related work.