سنتز تك ظرف وسه جزيي مشـتقات جديـد2H-پيرولو[2،3-d]-پيريميدين-4،2-دي اون و 1H-بنزو[f]-ايندول-9،4-دي اون حاوي استخلافات هيدروكسي نفتوكينون, By Mohammad Reza Mohammadizadeh

Research

Title	One-pot three-components synthesis of new derivatives of 2H-pyrolo[2,3-d]-pyrimidine-2,4-dione and 1H-benzo[f]-indol-4,9-dione bearing hydroxynaphthoquinone substituents
Type	Thesis
Keywords	هتروسيكل ها، هيدروكسي نفتوكينون، مشتقات پيرول، پيريميدين
Researchers	Rayhaneh Alipour (Student) , Mohammad Reza Mohammadizadeh (Primary advisor) , Najmeh Nowrouzi (Advisor)

Abstract

At first, we found that the condensation reaction of phenylglyoxal, 2-hydroxynaphtoquinone and aminouracil derivatives leads to the efficient synthesis of 2H –pyrrolo[2,3-d] pyrimidine -2,4 - (3H) -dione derivatives in good yields. In the second part of the study, derivatives of 3-hydroxy-1,4-dihydronephthalen-2-yl-1H-benzo [f] indole-4,9-dione were prepared through the reaction of phenylglyoxal, 2-hydroxy naphthoquinone and 3-amino-1,4-naphthoquinone derivatives in the presence of acetic acid and water as solvent and under reflux conditions