The goal of this paper is to investigate the temporal variation of scour depths and bed topography in the presence of a group of six vertical and inclined piers placed in a 180-degree bend flume. For this purpose, a series of tests were performed in a test flume provided by Hydraulics Laboratory of Persian Gulf University, Bushehr, Iran. The piers were placed at the angle of 60-degree of the bend flume. The flume is 1 meter wide with central radius to width ratio of 2 and has two straight sections at its upstream and downstream with 6.5 m and 5.1 m length, respectively. The results showed the temporal evolution of scour depth was decreased with passage of time. Also, the location of maximum scour depth was with time, so that it moved from the vicinity of the inner bank at the beginning of the tests towards the middle of the flume at the middle of the tests’ periods and the outer bank at the end of the tests. Also, the beginning of the scour holes near the inner bank and outer bank were different. However, this difference was decreased by passage of the time.