02 دی 1403
نجمه نوروزي

نجمه نوروزی

مرتبه علمی: استاد
نشانی: دانشکده علوم و فناوری نانو و زیستی - گروه شیمی
تحصیلات: دکترای تخصصی / شیمی
تلفن: -
دانشکده: دانشکده علوم و فناوری نانو و زیستی

مشخصات پژوهش

عنوان Application of PEG-400 as a green biodegradable polymeric medium for the catalyst-free synthesis of spiro-dihydropyridines and their use as acetyl and butyrylcholinesterase inhibitors
نوع پژوهش مقالات در نشریات
کلیدواژه‌ها
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مجله BIOORGANIC & MEDICINAL CHEMISTRY
شناسه DOI
پژوهشگران علیرضا حسنی نژاد (نفر اول) ، نجمه نوروزی (نفر دوم) ، غلامحسین محبی (نفر سوم) ، بهور اصغری (نفر چهارم)

چکیده

A simple, efficient and green approach for the synthesis of spiro-dihydropyridines derivatives by one-pot multi-component reaction of isatin or acenaphthoquinone derivatives (1 equiv) with malononitrile (1 equiv) and N,N0-substituted-2-nitroethene-1,1-diamines (1 equiv) in PEG-400 under catalyst-free conditions is described. This method provides several advantages such as environmental friendliness, short reaction time, and simple workup procedure for the synthesis of biologically important compounds. The ability of synthesized compounds in inhibition of acetyl and butyrylcholinesterase were investigated both in vitro and in silico. All compounds showed moderate to high level activity against both acetyl and butyrylcholinesterase. There was a good correlation between in vitro and in silico studies.