Background: Carbon-carbon bond cleavage has attracted much attention as an important research topic in recent years. The selective breaking of this bond by transition metals as a unique strategy allows chemists to approach desired molecules by reorganizing existing molecular skeletons. But according to the environmental and economic point of view, the development of metal-free organic reactions in modern organic synthesis, especially in the pharmaceutical industry, has received much attention due to the prevention of metal pollution. Benzamides are present in the skeleton of natural products, drugs, pesticides and functional materials. Usually, amine benzoylation is done by reacting amines with benzoyl chloride, benzoic anhydride, or other benzoylating reagents. Benzoylating reagents such as benzoyl chloride and benzoic anhydride are usually sensitive to moisture. As a result, their maintenance and related process becomes complicated. In this way, it is important to develop methods for forming amide bonds without using metal catalysts and carboxylic acid derivatives and finding suitable alternatives for it.
Aim: The aim of this study is the synthesis of amide compounds using benzoin and amines without the need for catalysts and solvents through breaking the carbon-carbon bond.
Methodology: In this section, the reaction between benzoin and aniline derivatives to synthesize amides was investigated. At first, the reaction conditions were optimized by screening the solvent and using different amounts of substrates and catalysts in different solvents and temperatures, and finally, the solvent was not used in the reaction. The obtained optimal conditions were used to prepare other amide derivatives.
Conclusions: In this research, a method for the synthesis of amides, which are nitrogenous compounds with various natural and medicinal properties, is presented. In this method, benzoin is used as the carbonyl source of the amide part and anilines are used as the nitrogen sour