One-pot synthesis of pyridopyrimidines via reaction of enaminones or uracils with in situ generated Chalcones, By Najmeh Nowrouzi

Research

Title	One-pot synthesis of pyridopyrimidines via reaction of enaminones or uracils with in situ generated Chalcones
Type	Presentation
Keywords	pyridopyrimidine; quinoline; chalcone; enaminone; uracil
Researchers	Najmeh Nowrouzi (Second researcher)

Abstract

A one-pot reaction is presented for the synthesis of pyridopyrimidine and quinoline derivatives, which are nitrogen-containing heterocyclic compounds with various medicinal properties. Chalcone derivatives are generated in situ from the reaction of aldehyde and ketone derivatives, then trapped by enaminone or uracil to produce the corresponding pyrido[2,3-d] pyrimidine and quinoline derivatives.