Metal-free C-H thioarylation of uracils and in situ generated enaminones using thiols in the presence of hexachloroethane, By Najmeh Nowrouzi

Research

Title	Metal-free C-H thioarylation of uracils and in situ generated enaminones using thiols in the presence of hexachloroethane
Type	Article
Keywords	Thioarylation Hexachloroethane Enaminone Uracil Metal-free
Journal	TETRAHEDRON LETTERS
DOI	10.1016/j.tetlet.2024.155320
Researchers	Najmeh Nowrouzi (Second researcher) , Mohammad Abbasi (Third researcher)

Abstract

A metal-free and one-pot procedure for thioarylation of uracils and in situ generated enaminones with thiols in the presence of C2Cl6 is introduced. This protocol is a less toxic alternative to other conventional thioarylation techniques because it uses hexachloroethane as a solid oxidant, which is stable, inexpensive, readily available and easier to work with.