Self-catalyzed, reaction of benzyl halides, Na2S2O3, and amines: a one-pot, simple, and efficient route to thiobenzamides, By Najmeh Nowrouzi

Research

Title	Self-catalyzed, reaction of benzyl halides, Na2S2O3, and amines: a one-pot, simple, and efficient route to thiobenzamides
Type	Article
Keywords	benzyl halides Na2S2O3, amines: thiobenzamides
Journal	Journal of Sulfur Chemistry
DOI	/10.1080/17415993.2025.2473737
Researchers	naser zarin derakht (First researcher) , Mohammad Abbasi (Second researcher) , Najmeh Nowrouzi (Third researcher)

Abstract

A new efficient, one-pot method to get thiobenzamide compounds from benzyl halides, amines, and Na2S2O3 is reported. A benzylic halide is treated with Na2S2O3 in DMSO until the halide is completely consumed. Next, the reaction is continued by adding a primary or secondary amine to the reaction mixture to synthesize thiobenzamides simply. This procedure does not require a special catalyst or any additive to afford thiobenzamides in good to excellent yields.