Abstract
Background: Today, obesity is closely related to metabolic syndrome and especially type 2 diabetes, which changes the
secretion and release of adipocytokines, and different training programs have different results on these indicators.
Therefore, the aim of the present study is to investigate the durability of changes caused by exercise programs on
adipocytokine indices of obese type 2 diabetic patients.
Methods: In this semi-experimental study, 45 obese men with type 2 diabetes were randomly divided into a control
group (no exercise) and 4 exercise groups (aerobic, combined, resistance and high-intensity interval). The exercise
program of the groups was considered based on the calories consumed in each session. The participants performed 12
weeks of training programs and 12 weeks of non-training. Physiological, anthropometric indicators and inflammatory
and pro-inflammatory indicators (IL-6, TNF-α, resistin and leptin) and anti-inflammatory indicators (adiponectin and
SFRP5) were measured before the program and at weeks 6, 12, 18 and 24. became.
Results: After 12 weeks of combined, aerobic, high intensity and resistance training, anti-inflammatory indices
(adiponectin and SFRP5) showed a significant increase compared to the baseline (before starting the training program)
(P< 0.05). Regarding pro-inflammatory and anti-inflammatory indicators (IL-6, TNF-α, resistin and leptin), a significant
decrease was observed in all groups after 12 weeks of training program (P< 0.05). In this study, a significant improvement
in weight loss and blood glucose was observed after 12 weeks of exercise program in all 4 exercise groups (P< 0.05). In
the second part of the findings (non-training or durability of training effect), it was resistance training that showed a
lower percentage decrease (P< 0.05) in anti-inflammatory indices and an increase in pro-inflammatory and inflammatory
indices after 12 weeks of non-training, which showed the durability It shows more recovery in obese type