Abstract
Background & Aims: Obesity increases the risk of various diseases, such as type 2 diabetes,
non-alcoholic fatty liver disease (NAFLD), cardiovascular diseases and some cancers (1). The
reports of the World Health Organization show that the occurrence of 4 million deaths per year
may be directly related to overweight or obesity (1). Obesity is a low-grade chronic
inflammatory condition that is closely related to atherosclerosis, high blood pressure, and
insulin resistance (4). Also, thermodynamically, obesity is the result of the relationship
between more energy intake and less energy consumption. Therefore, finding ways to increase
energy expenditure may help fight obesity. Ellagic acid (EA) is one of the types of polyphenols
in which the strong hydrogen bond network acts as an electron acceptor, which enables it to
participate in a number of reactions. This polyphenol is found naturally in many fruits and
vegetables, including strawberries, red raspberries, pomegranates, and grapes (11). EA can
reduce the symptoms of chronic diseases such as dyslipidemia, insulin resistance in type 2
diabetes and NAFLD (12). Most of the conducted studies showed that in addition to saving
time, HIIT compared to MICT leads to more weight loss, especially visceral fat mass and more
improvement in metabolic profile and cardiorespiratory health in obese people (17, 18).
Previous researches did not examine pro-inflammatory factors and due to the lack of clinical
studies on the effects of EA supplementation on metabolic diseases and the lack of studies on
the simultaneous effect of HIIT and antioxidant supplements on the immune system status of
people. increasing obesity in Iranian women due to lifestyle and diets, the current research
tries to answer the question of whether doing intense intermittent exercise and supplementing
with ellagic acid at the same time has an effect on the inflammatory status of overweight and
obese women.
Methods: This study was a double-blind randomized clinic