In the present study we investigated the transcription factor binding sites in the promoter regions of camel PRLR gene and evaluated them with those placed in domestic animal. After obtaining the promoter region sequence from NCBI database, discovering the transcription binding site was completed with PROMO online software, and their results were evaluated for similarities and differences by using Excel and Visual Basic softwares. The consequences demonstrated that the promoter region of the PRLR gene have various types of binding sites for transcription factors. Although, a lot of common binding sites was detected between species, but some special binding sites were detected only in camel. In general, the present outcomes show that the transcription conditions of this gene are often similar between species, but in special conditions are different from one species to another species.