The aim of this study was to determine the effectiveness of drama therapy on social skills and general self-esteem of learners with learning disabilities. The research method was quasi-experimental with a pretest-posttest design with a control group. The sample of the study was 22 male and female students with learning disabilities in primary school who were selected in a way in Bushehr Learning Disabilities Center. The experimental group participated in the sessions of the theater therapy group for 8 sessions. Tools used, Matson Social Skills Questionnaire and Coopersmith Budget Self-Esteem Test. The results of multivariate analysis of covariance showed that there was a difference between the experimental and observation groups in the variables of general self-esteem, aggression and impulsive behavior, peer relationship and appropriate social skills (P <0.01). But there was no significant difference in antisocial and hegemonic behavioral variables. This study showed that theater therapy is effective in increasing students' social skills and self-esteem as a result of learning disabilities.