Yousef Dehghani

Multiple sclerosis is a disease of the central nervous system that cause major psychological challenging in the patient all over the world. In this case, psychological interventions can be useful this study was aimed to predictor factors of adherence to treatment in patient with multiple sclerosis. This was on descriptive study with questionnaire. One hundred – twenty patients were selected through accessible sampling method from MS society of Tehran. They completed all administered demographic questionnaire , Multiple Sclerosis Treatment Adherence Questionnaire (MSTAQ) , General Self efficacy (GSE) , NEO five factor inventory (NEO-FFI) , Beck Depression Inventory (BDI) , Short Form health survey questionnaire (SF-36) , Kattle Anxiety Inventory (KAI) , Positive And Negative Affect Scales (PANAS) , Philips Social Support Questionnaire (SSQ) and Feedback . Data was analyzed using MONOVA repeated measure design , descriminent analysis and logistic regression . The finding of this study indicated that there is a significant difference in adherence in Multiple Sclerosis with depression , neuroticism , entroversion , conscientiousness , quality of life , family social support and anxiety (a=0/05) . The Results show that adherence has direct relationship with psychological factors . Better treatment for this patient in addition to medication should also be psychological counseling. This method can reduce anxiety and depression and increase self efficacy and improve quality of life