10 فروردین 1403
عبدالمحمد مهران پور

عبدالمحمد مهران پور

مرتبه علمی: دانشیار
نشانی: دانشکده علوم و فناوری نانو و زیستی - گروه شیمی
تحصیلات: دکترای تخصصی / شیمی آلی
تلفن: 07733445977
دانشکده: دانشکده علوم و فناوری نانو و زیستی

مشخصات پژوهش

عنوان
سنتز نمکهای وینامیدینیوم جدید با استفاده از واکنش های تعویض امین
نوع پژوهش پارسا
کلیدواژه‌ها
new vinamidinium salts, methyl groups, 1,5 positions
پژوهشگران خضر شورکی (دانشجو) ، عبدالمحمد مهران پور (استاد راهنما) ، صدیقه هاشم نیا (استاد مشاور)

چکیده

Synthesis of natural products with vinamidine system (1,5-diaza-1,3-pentadiene) is of interest for many reasons. They are found in red beets and other as the betacyanin pigments [1]. They are reactive towards electrophiles at C? and nucleophiles at C? and therefore they have tendency to undergo substitution instead of addition reactions. Reactions of vinamidinium salts with nucleophiles are of special preparative value: they lead e.g. to pyrazoles, oxazoles, pyrimidines, diazepines, quinolines, and quinolizines [2]. In this work we aimed to synthesis of some new vinamidinum salts using replacing NMe2 groups with aniline. Methods:10 mmol of the appropriate vinamidinium salt and 28 mmol of the required aniline were heated under reflux for 6 h in 25 ml of methanol. The oily phase was separated from the reaction mixture and methanol was added to the mixture. After 30 min stirring, the resultant vinamidine was filtered off, washed with cold methanol and dried. Results: The structures of all the newly synthesized compounds were confirmed by IR, 1H NMR, 13C NMR spectroscopy and as well as mass spectrometry.