May 2, 2024
Sadegh Karimi

Sadegh Karimi

Academic Rank: Associate professor
Address: Department of Chemistry, Faculty of Nano, Bioscience and Technology
Degree: Ph.D in Chemistry
Phone: 07731222074
Faculty: Faculty of Nano and Biotechnology

Research

Title
Mechanisms of electrochemical oxidation of febantel drug
Type Thesis
Keywords
فبانتل، اكسيداسيون الكتروشيميايي، ولتامتري چرخه اي،كولومتري، مكانسيم الكتروشيميايي
Researchers samira mohamadi (Student) , Esmail Tammari (Primary advisor) , Sadegh Karimi (Advisor)

Abstract

Background: Electrochemistry is a very good way to study the mechanism of chemical reactions and to determine the sequence of chemical and electrochemical reactions. A large part of this field is the study of chemicals and chemical changes caused by the passage of electric current and the production of electrical energy by chemical reactions, which means the measurement of electrical quantity such as current, Potential or charge and their relationship to chemical parameters. Aim: Due to the fact that not much research has been done on the electrochemical oxidation mechanism of Febantel, in this study the mechanism of electrochemical oxidation of Febantel and the relative simulation of its metabolism in animals using cyclic voltammetry are studied. . Methodology: In this thesis Electrochemical oxidation of Febantel in the presence and absence of sodium benzenesulfinicacid in acetonitrile and tetra butylammonium-perchlorate solution using cyclic voltammetry on the surface of glassy carbon electrode and coulometry in a double-walled cell containing Three graphite electrodes and an Ag / AgCl reference electrode and a platinum auxiliary electrode were performed at constant potential. Conclusions: The results of the cyclic voltammogram analysis showed that the first electrochemical oxidation of Febantel was of the quasi-reversible type, during which two electrons and two protons were transferred. And the second oxidation of the febantel is of the irreversible type, during which two electrons are transferred and has an EE mechanism. Further study of febantel cycle cyclic voltammograms in the presence and absence of sodium, benzene, sulfonic acid showed that the oxidized form of febantel participated in an adverse reaction of type 1 and 4 by Michael and reacted with nucleophiles. Vick follows the electrochemical mechanism of ECE.