After drilling oil and gas wells, the well is sealed and secured by piping and cementing in order to create strength, prevent the well from collapsing, prevent eruption, and control the entry of any fluid. Cementing operation is one of the most important and costly operations in the entire life of a well, and the useful life of the well directly depends on the quality of cementing. On the other hand, cementing operation is one of the most challenging operations, because in cementing, the cement slurry faces a porous environment from the well wall, which happens to have high temperature and pressure, and this design and cement engineering faces a serious challenge. One of the most fundamental challenges of drilling cement is the fluid loss of drilling cement slurry, which occurs due to the special conditions of the well environment, and if not controlled, it causes irreparable damage to the well and makes the cementing operation fail. From the past until now, in order to control the fluid loss of cement slurry, various additives have been used in the design of cement. In this study, by benefiting from the science of nanotechnology and using the special properties that nano particles can create, while carefully studying and understanding the existing mechanisms, it has been tried to identify and introduce effective nanoparticles in the control of drilling cement contamination. The main goal of this research is to identify special nanoparticles that can solve the problems of past additives by using their combined properties and while controlling fluid loss, other basic properties of cement can be improved or maintained. In this research, after studying and in-depth knowledge of the subject, a laboratory program was designed and implemented to investigate the effect of different nanoparticles on the performance of drilling cement, which led to great achievements, including the identification and synthesis of valuable nanoparticles and nanocomposites for the first time,