Background: A novel and efficient one-pot synthetic strategy has been developed for the simultaneous preparation of 3,5-diphenyl-4H-1,2,4-triazol-4-amine by reacting hydrazine hydrate with symmetrical diaryl disulfides in the presence of sodium thiosulfate (Na₂S₂O₃) as a sulfur-transfer agent. The reaction proceeds under mild conditions, eliminating the need for toxic reagents or expensive catalysts. These compounds exhibit various biological activities, including antimicrobial, anti-inflammatory, and anticancer properties. Traditional synthetic routes to these compounds often involve multi-step processes with limited yields. Therefore, the development of efficient and straightforward synthetic methodologies is of great importance. The one-pot approach simplifies the synthetic procedure, reduces reaction time, and minimizes the need for intermediate purifications, offering a robust and practical solution for the synthesis of bioactive thiazole compounds.
Methods: This study involves the one-pot synthesis of 3, 5-diphenyl-4H-1, 2, 4-triazol-4-amine. The reactants, Benzyl mercaptan, potassium carbonate, and hydrazine hydrate are reacted in the presence of sodium thiosulfate pentahydrate in DMSO at 80°C. After the reaction is complete the product is extracted and recrystallized for further purification.
Results: Benzyl mercaptan and hydrazine hydrate are effectively converted into 3, 5-diphenyl-4H-1, 2, 4-triazol-4-amine in the presence of sodium thiosulfate pentahydrate.
Conclusion: We developed an easy, efficient, and fast one-pot method for the synthesis of triazoles and thiadiazoles using inexpensive and readily available materials, including Benzyl mercaptan, potassium carbonate, hydrazine hydrate and sodium thiosulfate pentahydrate.
