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Abstract
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An efficient and simple protocol for the Heck reaction of aryl iodides and bromides using NiCl2$6H2O as
the pre-catalyst is presented. The reactions proceed well in ethylene glycol in the absence of phosphine
ligands and reducing agent. Compared to the frequently used expensive palladium catalysts, the use of
nickel catalyst has an economic advantage and hence, remains attractive for large or industrial scale
preparations. The efficient copper- and phosphine-free Sonogashira coupling reaction of aryl iodides is
also demonstrated using this catalytic system.
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