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Abstract
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In this work, highly e?cient, green and inexpensive procedures for the preparation of quinoxaline
and quinoline derivatives as attractive aza-polycyclic compounds are described. Silica
nanoparticles-catalyzed condensation of 1,2-diamines with 1,2-diketones under solvent-free
conditions at room temperature a?ords high yields of quinoxalines with short reaction times.
Moreover, the microwave-assisted Friedlander hetero-annulation reaction between 2-aminoaryl
ketones and carbonyl compounds in the presence of silica nanoparticles (NPs) as catalysts gives
high yields of quinoline derivatives with short reaction times. These reactions have been done in
neutral conditions. The NPs catalysts can be reused without lost of activity even after recycling
fourteen times .
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