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Title
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Design of ionic liquid 1,3-disulfonic acid imidazolium hydrogen sulfate as a dual-catalyst for the one-pot multi-component synthesis of 1,2,4,5-tetrasubstituted imidazoles
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Abstract
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Novel ionic liquid 1,3-disulfonic acid imidazolium hydrogen sulfate {[Dsim]HSO
} ef?ciently catalyzes
the synthesis of 1,2,4,5-tetrasubstituted imidazoles via the one-pot multi-component condensation of
benzyl with aldehydes, primary amines and ammonium acetate at 90 8C under solvent-free conditions.
Dual hydrogen-bond donors can be used to direct the assembly of this catalyst and the ef?ciency of it.
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