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Abstract
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A convenient synthesis of substituted spiroindenoquinoxalines at mild and green conditions was
developed. Multicomponent reaction of substituted phenylene diamines, ninhydrin,
malononitrile and N,N’-substituted-2-nitroethene-1,1-diamines produced the target compounds.
Twelve new spiroindenoquinoxalines were obtained, and their ability in inhibition of acetyl and
butyrylcholinesterases were investigated both in-vitro and in-silico. All compounds showed
moderate level activity against both acetyl and butyrylcholinesterases.
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