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Abstract
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The synthesis of new derivatives of pyrrole substituted sulfonamide groups is described. The in vitro
anticancer activity of these pyrroles was evaluated against MCF7, MOLT-4 and HL-60 cells using MTT
assay. The target compounds showed inhibitory activity against tested cell lines. Among the compounds,
compound 1a exhibited good cytotoxic activity. The potential of this analog to induce apoptosis was
confirmed in a nuclear morphological assay by Hoechst 33258 staining in the PC-12 cells. Finally, molecular
docking was performed to determine the probable binding mode of the designed pyrrole derivatives
into the active site of FGFR1 protein. DFT calculations were carried out at the B3LYP levels of
theory with 6-31?G (d,p) basis set for compound 1a. The point group (C1) of it was obtained based on the
optimized structures; the calculation of the FT-IR vibrational frequencies, 1H NMR and 13C NMR chemical
shifts of the compound were carried out and compared with those obtained experimentally.
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