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The role of endoplasmic reticulum stress in the regulation of long noncoding RNAs in cancer
Type Article
cell survival, ER stress, long noncoding RNAs, signaling pathways, unfolded protein response (UPR)
Cancer cells must overcome a variety of external and internal stresses to survive and proliferate. These unfavorable conditions include the accumulation of mutations, nutrient deficiency, oxidative stress, and hypoxia. These stresses can cause aggregation of misfolded proteins inside the endoplasmic reticulum. Under these conditions, the cell undergoes endoplasmic reticulum stress (ER‐stress), and consequently initiates the unfolded protein response (UPR). Activation of the UPR triggers transcription factors and regulatory factors, including long noncoding RNAs (lncRNAs), which control the gene expression profile to maintain cellular stability and hemostasis. Recent investigations have shown that cancer cells can ensure their survival under adverse conditions by the UPR affecting the expression of lncRNAs. Therefore, understanding the relationship between lncRNA expression and ER stress could open new avenues, and suggest potential therapies to treat various types of cancer.
Researchers Nasim Ebrahimi (First researcher) , Jamileh Saremi (Second researcher) , Masoud Ghanatian (Third researcher) , Elnaz Yazdani (Fourth researcher) , Samaneh Adelian (Fifth researcher) , Sahar Samsami (Not in first six researchers) , Neda Moradi (Not in first six researchers) , Amirhossein Ahmadi (Not in first six researchers) , Michel Hamblin (Not in first six researchers) , Amir Reza Aref (Not in first six researchers)