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Abstract
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Pd-catalyzed domino processes involving CC/CN coupling of in situ generated enaminones with alkynes in the absence of a
directing group on nitrogen has been developed. In this protocol, linear and cyclic 1,3-diketones in the reaction with aliphatic
amines and diphenylacetylene derivatives provides efficient access to substituted pyrroles through Pd-catalyzed C-H activation of enaminones. Using aromatic amines instead of aliphatic amines does not accomplish this organic transformation due to the
formation of carbazolone. In this method, there is no need for active acetylene compounds, and also, unlike a number of previously reported methods, the reaction is performed without the presence of a directing group on nitrogen, thus highlighting a useful synthetic application of the present catalytic protocol.
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