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Abstract
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Iodine-mediated selective synthesis of ?-uramino crotonic esters was achieved via the reaction of ?-dicarbonyls and urea at
room temperature. Choline chloride/urea mixture, as an eco-friendly, cheap, non-toxic, and recyclable deep eutectic solvent
(DES), was employed as sustainable media as well as reagent at the same time in these transformations. Some derivatives
of ?-uramino crotonic esters were synthesized with good to high yields without a tedious work-up. The process could be
done to synthesize the above-mentioned compounds in gram scale. Moreover, oxidative cross-esterifcation of carboxylic
acids with alkyl benzenes was carried out in the above-mentioned DES by the employment of tetrabutylammonium iodide
(TBAI) as the catalyst and tert-butyl hydroperoxide (TBHP) as the oxidant at 80 °C. DES/TBAI system was reused up to
five consecutive times
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