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Abstract
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A simple, clean, and highly efficient solvent-free procedure for the preparation of bis(1H-indol-3-yl)methanes is described from the reaction of carbonyl compounds (aldehydes and ketones) with 1H-indole in the presence of trityl chloride as a catalyst. The reaction proceeds rapidly in high yields at room temperature in a neutral medium. A proposed mechanism is suggested based upon former reactions and calculated results.
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